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Product details
File Size: 1101 KB
Print Length: 241 pages
Publisher: BenBella Books; 1 edition (October 6, 2015)
Publication Date: October 6, 2015
Sold by: Amazon Digital Services LLC
Language: English
ASIN: B014C58SAM
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Amazon Best Sellers Rank:
#263,523 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
As an aging physician(ophthalmologist) who has been interested in aging, that is, how to delay it, and if possible reverse it, I have studied every claim to these ends and indulged in the few which seemed reasonable. Dr. Fossel, who has written the only medical textbook on cellular aging in existence, explains how telomere loss leads to increasing cellular senescence and eventual death,with the subsequent death of the organism. He cites some lower organisms which never die until eaten because telomeres are maintained. Most significantly, he explains how activation of the dormant gene in our cells for the enzyme which builds telomeres will reverse cellular aging, and therefore prevent a host of degenerate diseases. It has already been done in the lab on tissues and even in some artificially aged lower animals.This book is written for educated laymen as well as physicians. It is to the point, logical, and In my opinion compelling. Very well written. The explanation on how telomere loss leads to specific diseases alone is worth the read. There is even a reasonable speculation of why evolution would 'select' death for all of us individual organisms.This is something to get excited about! It looks like the 'real McCoy' of age reversal! Read it and gain hope!
Fossel writes about a simple and speculative idea: cell aging is caused by a shortening of the telomeres (which impacts gene expression) and, in turn, cell aging causes our aging. There is some but overall little evidence in favor of this theory. However, if the theory is even just partially correct, it could have deep consequences. And even if it is wrong, the whole topic is still fascinating.This is an enjoyable book, so I gave 5 stars. It is not a textbook... this is just a fun book to read over the week-end. The author kept jargon to a minimum. He gives all the references supporting his theory, but he does not go into the details of the recent research, presenting instead an overview...As some reviewers have remarked, Fossel gives himself a central role in the story. It is told as a personal story. It did not bother me.To answer some possible objections...- If this is so promising... why has this not been pursued and completed already?Well. Research on telomerase was granted a Nobel prize, so there has been plenty of research.- But why has this not been pursued more agressively as a therapy?We have been working for decade on a cure for the HIV virus, and we are not there yet. It is one thing to identify a potential line of attack and quite another to develop and test an actual therapy.You can't eat telomerase and expect it to end up in your genes.There are stories of people who might have undergone gene therapy so that some of their cells produce telomerase. We should not be surprised if such work is not easy to fund and get approved by governemental bodies. But even if the telomere theory is correct... these particular therapies might very well fail or prove counterproductive if only because they may fail to elongate telomeres sufficiently.So it is bound to be a difficult road... moreover, as explained by Fossel, researchers are not eager to talk about the idea of reversing aging as it is too much of a disruptive idea.Is the telomere theory correct? We still have too little information to know...But I am not judging the theory, I am judging the book, and it is fun!My only criticism would be that Fossel clearly loses all critical sense toward the end of the book, assuming without restraint that his theory is correct. It would have been more interesting had he spent time reviewing the evidence that is contrary to his theory. I would encourage him to do so in a follow-up edition.
Great book....But the author does not believe in what the co-authors of his earlier book,: "The Telemere Effect" said about using certain supplements and vitamins to help lengthen your Telemeres. And one of the co-authors was awarded the Nobel Prize, Elizabeth Blackburn, for discovering Telemeres. Dr. Fossel wanted proof about this, which is understandable from a scientist.....
Here's a book that readies you for the future. The author, Michael Fossel, brings credentials and credibility to the task of outlining how current research will deliver human longevity. In a clear, lucid style, the author relates the history, current work, and projected benefits from an enzyme called "telomerase." Normally not produced by mature, differentiated cells, telomerase adds a specific DNA sequence to the ends of a cell's chromosomes, the regions called "telomeres." Once lengthened, the unique happens: cells live longer, easily breaking through the Hayflick Limit, imparting an extended lifespan to the whole organism. I enjoyed how Fossel packs his tome with facts and references supporting his projection that, within a decade, a viable and inexpensive Fountain of Youth will be found. Get this book. Be prepared.
Telomere extenders have been around for a decade and research is accelerating. Apparently all chronic diseases can be the traced back to aging induced by shortening telomeres.
Dr Fossel takes you on a trip through the evolution of a scientific revolution. He covers many aspect of today's achievements and paints a plausible and positive future for our lives and health.
Great book. I am well educated in the subject of aging but this work gives new thoughts and ideas.
A very no-nonsense informative book. The only viable way to live a long healthy life is by telomerase activation, exercise and a diet that is tailored for you, and by you, on a try and see basis.
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